The PET & Cyclotron Unit at Copenhagen University Hospital is organized under the Department of Clinical Physiology and Nuclear Medicine and supplies the TAT-group with 211At.
The Cyclotron Unit is focused on producing PET isotopes such as 18F, 13N, 11C, and 15O for the use at the 6 PET and PET/CT scanners in the department. But it also supplies FDG on a daily basis to different customers in the Copenhagen area. Besides this they have a large production of Rubidum/Krypton-generators and finally they produce several unique isotopes like 211At and 111mCd. The latter productions can only be done with the Scanditronix MC32 cyclotron due to the high energy and the possibility of making alpha-particle-beams.
For more information about the PET & Cyclotron Unit please visit the web page of the Department of Clinical Physiology and Nuclear Medicine
Fig. 1. The image shows the Scanditronix MC32 cyclotron at Rigshospitalet in Copenhagen. Click image for higher resolution.
The collaboration since 2000 with the Cyclotron Unit at Rigshospitalet consists of a continuous supply of irradiated 209Bi targets. The targets are irradiated by accelerated alpha particles in the cyclotron, and produces 211At via the nuclear reaction 209Bi(a,2n)211At. The targets are then transported to Gothenburg where the 211At is extracted by a dry distillation method (Appl Radiat Isot 2001;55:157-160) and later used in our preclinical and clinical studies.