The main research areas in the TAT Group range from studies of the labeling chemistry of radionuclides to different ligands, studies of pharmacokinetics and different aspects of radiation physics such as dosimetry, to clinical studies in which treatment strategies are evaluated, such as in our recently completed phase I study.
Fig. 1. Upper left: Anteroposterior gamma-camera scan of the abdominal and thoracic area after infusion of 211At-MX35 F(ab´)2 in a patient in the phase I study. Upper right: Distribution of 211At-IgG in mouse kidney 2 h after i.v. injection visualized in a 20 µm cryosection using the Alpha Camera. Lower left: Scanning electron microscopy image showing a small tumor loosely adhered to the peritoneum in a mice. Lower right: Double-strand breaks, visualized as H2AX-foci, in cells irradiated with 1 Gy by alpha particles. Particle passages across the whole nucleus are seen in some cells.